Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing

Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing

In the era of “Bad Bugs, No Drugs,” optimizing antibiotic therapy against multi-drug resistant (MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize dosing regimens. These models include mechanism-based PK/PD models, systems-based models, quantitative systems pharm...

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Bibliographic Details
Main Authors: Hui-Yin Yow, Kayatri Govindaraju, Audrey Huili Lim, Nusaibah Abdul Rahim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
antimicrobial therapy
pharmacokinetic/pharmacodynamic (PK/PD)
mechanism-based PK/PD models
multi-omics
systems pharmacology
precision dosing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.915355/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.915355/full

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