Escaping from CRISPR–Cas-mediated knockout: the facts, mechanisms, and applications

Abstract Clustered regularly interspaced short palindromic repeats and associated Cas protein (CRISPR–Cas), a powerful genome editing tool, has revolutionized gene function investigation and exhibits huge potential for clinical applications. CRISPR–Cas-mediated gene knockout has already become a rou...

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Bibliographic Details
Main Authors: Ying Wang, Yujing Zhai, Mingzhe Zhang, Chunlin Song, Yuqing Zhang, Gang Zhang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
Online Access:https://doi.org/10.1186/s11658-024-00565-x