Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists.

Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists.

Although there is no shortage of potential drug targets, there are only a handful known low-molecular-weight inhibitors of protein-protein interactions (PPIs). One problem is that current efforts are dominated by low-yield high-throughput screening, whose rigid framework is not suitable for the dive...

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Bibliografische gegevens
Hoofdauteurs: David Koes, Kareem Khoury, Yijun Huang, Wei Wang, Michal Bista, Grzegorz M Popowicz, Siglinde Wolf, Tad A Holak, Alexander Dömling, Carlos J Camacho
Formaat: Artikel
Taal:English
Gepubliceerd in: Public Library of Science (PLoS) 2012-01-01
Reeks:PLoS ONE
Online toegang:http://europepmc.org/articles/PMC3299697?pdf=render

Internet

http://europepmc.org/articles/PMC3299697?pdf=render

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