Cav3.2-dependent hyperalgesia/allodynia following intrathecal and intraplantar zinc chelator administration in rodents

Cav3.2-dependent hyperalgesia/allodynia following intrathecal and intraplantar zinc chelator administration in rodents

Cav3.2, a T-type calcium channel (T-channel) family member, is expressed in the nociceptors and spinal cord, and its activity is largely suppressed by zinc under physiological conditions. In rats, intrathecal and intraplantar administration of a zinc chelator, TPEN, caused T-channel-dependent mechan...

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Bibliographic Details
Main Authors: Shiori Tomita, Fumiko Sekiguchi, Katsuki Naoe, Shiyu Shikimi, Yoshihito Kasanami, Maya Ohigashi, Maho Tsubota, Atsufumi Kawabata
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Cav3.2 T-type calcium channel
Pain
Hyperalgesia
Zinc deficiency
TPEN
Online Access:http://www.sciencedirect.com/science/article/pii/S134786132300021X

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http://www.sciencedirect.com/science/article/pii/S134786132300021X

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