Independent Microevolution Mediated by Mobile Genetic Elements of Individual <named-content content-type="genus-species">Clostridium difficile</named-content> Isolates from Clade 4 Revealed by Whole-Genome Sequencing

Independent Microevolution Mediated by Mobile Genetic Elements of Individual <named-content content-type="genus-species">Clostridium difficile</named-content> Isolates from Clade 4 Revealed by Whole-Genome Sequencing

ABSTRACT Horizontal gene transfer of mobile genetic elements (MGEs) accounts for the mosaic genome of Clostridium difficile, leading to acquisition of new phenotypes, including drug resistance and reconstruction of the genomes. MGEs were analyzed according to the whole-genome sequences of 37 C. diff...

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Bibliographic Details
Main Authors: Yuan Wu, Chen Liu, Wen-Ge Li, Jun-Li Xu, Wen-Zhu Zhang, Yi-Fei Dai, Jin-Xing Lu
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mSystems
Subjects:
Clostridium difficile
antifungal resistance
horizontal gene transfer
microevolution
mobile genetic elements
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00252-18

Internet

https://journals.asm.org/doi/10.1128/mSystems.00252-18

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