Hierarchical generalized linear models for multiple groups of rare and common variants: jointly estimating group and individual-variant effects.
Complex diseases and traits are likely influenced by many common and rare genetic variants and environmental factors. Detecting disease susceptibility variants is a challenging task, especially when their frequencies are low and/or their effects are small or moderate. We propose here a comprehensive...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-12-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3228815?pdf=render |