Cinobufacini injection suppresses the proliferation of human osteosarcoma cells by inhibiting PIN1-YAP/TAZ signaling pathway

Cinobufacini injection suppresses the proliferation of human osteosarcoma cells by inhibiting PIN1-YAP/TAZ signaling pathway

Cinobufacini injection (CI), an aqueous extract of Cutis Bufonis, is clinically used for cancer therapy in China, but its molecular mechanism for the treatment of osteosarcoma (OS) remains unclear. We constructed U2OS ectopic subcutaneous tumor model to verify the anti-OS effect of CI in vivo. Meanw...

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Bibliographic Details
Main Authors: Yuru Chen, Yanyan Wang, Yu Zhai, Ye Yuan, Junhong Wang, Yajing Jin, Lingling Dang, Liming Song, Changbao Chen, Yu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
cinobufacini injection
osteosarcoma
PIN1
YAP
TAZ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1081363/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1081363/full

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