Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice

Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice

Background: Acute kidney injury (AKI) is a common syndrome impacting about 13.3 million patients per year. Tilianin has been reported to alleviate myocardial ischemia/reperfusion (I/R) injury, while its effect on AKI is unknown; thus, this study aimed to explore if tilianin protects I/R-induced AKI...

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Bibliographic Details
Main Authors: Zengying Liu, Chen Guan, Chenyu Li, Ningxin Zhang, Chengyu Yang, Lingyu Xu, Bin Zhou, Long Zhao, Hong Luan, Xiaofei Man, Yan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
tilianin
acute kidney injury
ischemia–reperfusion injury
ERK
EGR1
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.862584/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.862584/full

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