Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair

DNA mismatch repair (MMR) repairs replication errors, and MMR defects play a role in both inherited cancer predisposition syndromes and in sporadic cancers. MMR also recognizes mispairs caused by environmental and chemotherapeutic agents; however, in these cases mispair recognition leads to apoptosi...

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Bibliographic Details
Main Authors: Anna K. Miller, Guogen Mao, Breanna G. Knicely, Hannah G. Daniels, Christine Rahal, Christopher D. Putnam, Richard D. Kolodner, Eva M. Goellner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mismatch repair (MMR)
rad5
SHPRH
HLTF
alkylating agent MNNG
binding motif
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.843121/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.843121/full

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