The role of hypoxia-induced modulation of alveolar epithelial Na- transport in hypoxemia at high altitude
Reabsorption of excess alveolar fluid is driven by vectorial Na + -transport across alveolar epithelium, which protects from alveolar flooding and facilitates gas exchange. Hypoxia inhibits Na + -reabsorption in cultured cells and in-vivo by decreasing activity of epithelial Na + -channels (ENaC), w...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-09-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894020936662 |