CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization

CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization

Clustered regularly interspaced short palindromic repeats (CRISPR)-based genomic disruption of vascular endothelial growth factor A (Vegfa) with a single gRNA suppresses choroidal neovascularization (CNV) in preclinical studies, offering the prospect of long-term anti-angiogenesis therapy for neovas...

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Bibliographic Details
Main Authors: Sook Hyun Chung, Tzu-Ni Sin, Brian Dang, Taylor Ngo, Therlinder Lo, Daniella Lent-Schochet, Ratheesh K. Meleppat, Robert J. Zawadzki, Glenn Yiu
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
ocular gene therapy
AAV
CRISPR
AMD
neovascular AMD
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122000919

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http://www.sciencedirect.com/science/article/pii/S2162253122000919

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