Inhibition of Wnt/β-Catenin Signaling Sensitizes Esophageal Cancer Cells to Chemoradiotherapy

Inhibition of Wnt/β-Catenin Signaling Sensitizes Esophageal Cancer Cells to Chemoradiotherapy

The standard treatment of locally advanced esophageal cancer comprises multimodal treatment concepts including preoperative chemoradiotherapy (CRT) followed by radical surgical resection. However, despite intensified treatment approaches, 5-year survival rates are still low. Therefore, new strategie...

Full description

Bibliographic Details
Main Authors: Melanie Spitzner, Georg Emons, Karl Burkhard Schütz, Hendrik A. Wolff, Stefan Rieken, B. Michael Ghadimi, Günter Schneider, Marian Grade
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
esophageal cancer
chemoradiotherapy
treatment resistance
chemoradiotherapy-sensitization
Wnt/β-catenin pathway
tankyrase inhibition
Online Access:https://www.mdpi.com/1422-0067/22/19/10301

Internet

https://www.mdpi.com/1422-0067/22/19/10301

Similar Items