PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning

Excitotoxicity is the pathological process by which neuronal death occurs as a result of excessive stimulation of receptors at the excitatory synapse such as the NMDA receptor (NMDAR). Excitotoxicity has been implicated in the acute neurological damage from ischemia and traumatic brain injury and in...

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Bibliographic Details
Main Authors: Timothy Johanssen, Nuttawat Suphantarida, Paul S. Donnelly, Xiang M. Liu, Steven Petrou, Andrew F. Hill, Kevin J. Barnham
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000285