Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis

Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis

Abstract SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In differentiated CD4+ macrophage and resting T-cells SAMHD1 activity results in the inhibition of HIV-1 infection through a dNTP blockade. In...

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Bibliographic Details
Main Authors: Oliver J. Acton, Devon Sheppard, Simone Kunzelmann, Sarah J. Caswell, Andrea Nans, Ailidh J. O. Burgess, Geoff Kelly, Elizabeth R. Morris, Peter B. Rosenthal, Ian A. Taylor
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-48237-w

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https://doi.org/10.1038/s41467-024-48237-w

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