Facial Synthesis and Bioevaluation of Well-Defined OEGylated Betulinic Acid-Cyclodextrin Conjugates for Inhibition of Influenza Infection

Facial Synthesis and Bioevaluation of Well-Defined OEGylated Betulinic Acid-Cyclodextrin Conjugates for Inhibition of Influenza Infection

Betulinic acid (BA) and its derivatives exhibit a variety of biological activities, especially their anti-HIV-1 activity, but generally have only modest inhibitory potency against influenza virus. The entry of influenza virus into host cells can be competitively inhibited by multivalent derivatives...

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Bibliographic Details
Main Authors: Yingying Chen, Xinchen Wang, Xinyuan Ma, Shuobin Liang, Qianqian Gao, Elena V. Tretyakova, Yongmin Zhang, Demin Zhou, Sulong Xiao
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
lupane triterpene
click chemistry
antiviral activity
structure-activity relationships
multivalent
Online Access:https://www.mdpi.com/1420-3049/27/4/1163

Internet

https://www.mdpi.com/1420-3049/27/4/1163

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