Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

Monoclonal antibodies find broad application as therapy for various types of cancer by employing multiple mechanisms of action against tumors. Manipulating the Fc-mediated functions of antibodies that engage immune effector cells, such as NK cells, represents a strategy to influence effector cell ac...

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Bibliographic Details
Main Authors: Kristina M. Ilieva, Judit Fazekas-Singer, Daniela Y. Achkova, Tihomir S. Dodev, Silvia Mele, Silvia Crescioli, Heather J. Bax, Anthony Cheung, Panagiotis Karagiannis, Isabel Correa, Mariangela Figini, Rebecca Marlow, Debra H. Josephs, Andrew J. Beavil, John Maher, James F. Spicer, Erika Jensen-Jarolim, Andrew N. Tutt, Sophia N. Karagiannis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
antibodies
cancer immunotherapy
mutants
cloning
expression
ADCC
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01112/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01112/full

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