Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance

Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance

Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myogenic autoregulation are poorly understood. Here, we show tha...

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Bibliographic Details
Main Authors: Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
myogenic vasoconstriction
vascular smooth muscle
G-protein
Rho/Rho-kinase
myogenic tone
signal transduction
Online Access:https://elifesciences.org/articles/49374

Internet

https://elifesciences.org/articles/49374

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