Synthesis, Biological Evaluation and Molecular Docking Studies of 6-Aryl-2-Styrylquinazolin-4(3H)-Ones

Synthesis, Biological Evaluation and Molecular Docking Studies of 6-Aryl-2-Styrylquinazolin-4(3H)-Ones

Suzuki-Miyaura cross-coupling of 6-bromo-2-styrylquinazolin-4(3H)-ones with arylboronic acids afforded a series of novel 6-aryl-2-styrylquinazolin-4(3H)-ones. These compounds were evaluated for potential anticancer properties against the human renal (TK-10), melanoma (UACC-62) and breast cancer (MCF...

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Bibliographic Details
Main Authors: Emmanuel Ndubuisi Agbo, Tshepiso Jan Makhafola, Yee Siew Choong, Malose Jack Mphahlele, Ponnadurai Ramasami
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
6-bromo-2-styrylquinazolin-4(3H)-ones
Suzuki-Miyaura cross-coupling
6-aryl-2-styrylquinazolin-4(3H)-ones
in vitro cytotoxicity
antimicrobial activity
docking studies
Online Access:http://www.mdpi.com/1420-3049/21/1/28

Internet

http://www.mdpi.com/1420-3049/21/1/28

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