Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury

Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury

Abstract Background Neonatal hypoxic brain injury is a major cause of intellectual and developmental disability. Hypoxia causes neuronal dysfunction and death in the developing cerebral cortex due to excitotoxic Ca2+-influx. In the translational piglet model of hypoxic encephalopathy, we have previo...

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Bibliographic Details
Main Authors: Panagiotis Kratimenos, Abhya Vij, Robinson Vidva, Ioannis Koutroulis, Maria Delivoria-Papadopoulos, Vittorio Gallo, Aaron Sathyanesan
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Neonatal brain injury
Excitotoxicity
Src kinase
Calcium/calmodulin
Nuclear calcium
Computational modeling
Online Access:https://doi.org/10.1186/s11689-022-09431-3

Internet

https://doi.org/10.1186/s11689-022-09431-3

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