Development of 20(S)-Protopanaxadiol-Loaded SNEDDS Preconcentrate Using Comprehensive Phase Diagram for the Enhanced Dissolution and Oral Bioavailability

Development of 20(S)-Protopanaxadiol-Loaded SNEDDS Preconcentrate Using Comprehensive Phase Diagram for the Enhanced Dissolution and Oral Bioavailability

In this study, we aimed to develop a 20(S)-protopanaxadiol (PPD)-loaded self-nanoemulsifying drug delivery system (SNEDDS) preconcentrate (PSP) using comprehensive ternary phase diagrams for enhanced solubility, physical stability, dissolution, and bioavailability. Capmul MCM C8 and Capryol 90 were...

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Bibliographic Details
Main Authors: Young Hoon Kim, Yu Chul Kim, Dong-Jin Jang, Kyoung Ah Min, Jenisha Karmacharya, Thi-Thao-Linh Nguyen, Han-Joo Maeng, Kwan Hyung Cho
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
20(S)-protopanaxadiol
self-nanoemulsifying drug delivery system
comprehensive ternary phase diagram
oral bioavailability
Online Access:https://www.mdpi.com/1999-4923/12/4/362

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https://www.mdpi.com/1999-4923/12/4/362

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