Intravenous Administration of Ad26.COV2.S Does Not Induce Thrombocytopenia or Thrombotic Events or Affect SARS-CoV-2 Spike Protein Bioavailability in Blood Compared with Intramuscular Vaccination in Rabbits

Intravenous Administration of Ad26.COV2.S Does Not Induce Thrombocytopenia or Thrombotic Events or Affect SARS-CoV-2 Spike Protein Bioavailability in Blood Compared with Intramuscular Vaccination in Rabbits

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a very rare but serious adverse reaction that can occur after Ad26.COV2.S vaccination in humans, leading to thrombosis at unusual anatomic sites. One hypothesis is that accidental intravenous (IV) administration of Ad26.COV2.S or drainage...

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Bibliographic Details
Main Authors: Selina Khan, Sonia Marquez-Martinez, Tim Erkens, Adriaan de Wilde, Lea M. M. Costes, Petra Vinken, Sandra De Jonghe, Wendy Roosen, Chiara Talia, Ronnie Chamanza, Jan Serroyen, Jeroen Tolboom, Roland C. Zahn, Frank Wegmann
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Vaccines
Subjects:
adenovirus
viral vector
vaccine
platelets
rabbits
Online Access:https://www.mdpi.com/2076-393X/11/12/1792

Internet

https://www.mdpi.com/2076-393X/11/12/1792

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