Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals

Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals

Fragile X syndrome (FXS) is the most common form of monogenic intellectual disability and autism, caused by the absence of the functional fragile X messenger ribonucleoprotein 1 (FMRP). FXS features include increased and dysregulated protein synthesis, observed in both murine and human cells. Altere...

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Bibliographic Details
Main Authors: Giulia Cencelli, Laura Pacini, Anastasia De Luca, Ilenia Messia, Antonietta Gentile, Yunhee Kang, Veronica Nobile, Elisabetta Tabolacci, Peng Jin, Maria Giulia Farace, Claudia Bagni
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
Fragile X syndrome
APP processing
protein synthesis
peptide therapy
iPSCs
ADAM10
Online Access:https://www.mdpi.com/2073-4409/12/5/758

Internet

https://www.mdpi.com/2073-4409/12/5/758

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