Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram

Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram

Prefrontal-subcortical circuits support executive functions which often become dysfunctional in psychiatric disorders. Vortioxetine is a multimodal antidepressant that is currently used in the clinic to treat major depressive disorder. Mechanisms of action of vortioxetine include serotonin (5-HT) tr...

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Bibliographic Details
Main Authors: Shreaya Chakroborty, Thomas R. Geisbush, Elena Dale, Alan L. Pehrson, Connie Sánchez, Anthony R. West
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
vortioxetine
escitalopram
serotonin
prefrontal cortex
nucleus accumbens
lateral septum
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00764/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00764/full

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