Combined exposure to manganese and iron decreases oxidative stress-induced nerve damage by increasing Nrf2/HO-1/NQO1 expression

Combined exposure to manganese and iron decreases oxidative stress-induced nerve damage by increasing Nrf2/HO-1/NQO1 expression

Background: Manganese (Mn) and iron (Fe) are essential trace elements for humans, yet excessive exposure to Mn or Fe can accumulate in the central nervous system (CNS) and cause neurotoxicity. The purpose of this study was to investigate the effects of Mn and Fe exposure, alone or in combination, on...

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Bibliographic Details
Main Authors: Yuan-yuan Fang, Meng-jun Teng, Jian-chao Peng, Xiao-wei zheng, Ya-Qi Mo, Thanh-Tung Ho, Jun-jie Lin, Jing-jing Luo, Michael Aschner, Yue-ming Jiang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Manganese
Iron
Oxidative stress
Combined exposure
ROS
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132301357X

Internet

http://www.sciencedirect.com/science/article/pii/S014765132301357X

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