Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis

Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis

BackgroundPrimary hemophagocytic lymphohistiocytosis (pHLH) is an inherited inflammatory syndrome driven by the exuberant activation of interferon-gamma (IFNg)-producing CD8 T cells. Towards this end, ruxolitinib treatment or IFNg neutralization (aIFNg) lessens immunopathology in a model of pHLH in...

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Bibliographic Details
Main Authors: Sabrin Albeituni, Ninad Oak, Heather S. Tillman, Alexa Stroh, Camille Keenan, Mackenzie Bloom, Kim E. Nichols
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
hemophagocytic lymphohistiocytosis (HLH)
cytokines
inflammation
interferon-gamma (IFNg)
Janus kinase (JAK)
ruxolitinib
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1137037/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1137037/full

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