Fanca deficiency is associated with alterations in osteoclastogenesis that are rescued by TNFα

Fanca deficiency is associated with alterations in osteoclastogenesis that are rescued by TNFα

Abstract Background Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche, which includes bone-forming and bone-resorbing cells, i.e., osteoblasts (OBs) and osteoclasts (OCs). OBs originate from mesenchymal progenitors, while OCs are derived from HSCs. Self-renewal, proliferation and...

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Bibliographic Details
Main Authors: Alessia Oppezzo, Lovely Monney, Henri Kilian, Lofti Slimani, Frédérique Maczkowiak-Chartois, Filippo Rosselli
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell & Bioscience
Subjects:
Fanconi anemia
Osteoclast
Osteoblast
Cell signaling
TNFα
p53
Online Access:https://doi.org/10.1186/s13578-023-01067-7

Internet

https://doi.org/10.1186/s13578-023-01067-7

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