Fanca deficiency is associated with alterations in osteoclastogenesis that are rescued by TNFα
Abstract Background Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche, which includes bone-forming and bone-resorbing cells, i.e., osteoblasts (OBs) and osteoclasts (OCs). OBs originate from mesenchymal progenitors, while OCs are derived from HSCs. Self-renewal, proliferation and...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-06-01
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Series: | Cell & Bioscience |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13578-023-01067-7 |