Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model

Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model

A treatment with direct healing effects on the gastrointestinal epithelial barrier is desirable for inflammatory bowel disease (IBD). Interleukin-27 (IL-27) is an immunoregulatory cytokine, and oral delivery is an effective treatment in murine models of IBD. We aimed to define IL-27 effects on the h...

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Bibliographic Details
Main Authors: Daniel P. Brice, Graeme I. Murray, Heather M. Wilson, Ross J. Porter, Susan Berry, Scott K. Durum, Mairi H. McLean
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biology
Subjects:
IBD
colitis
cytokine
interleukin-27
epithelium
organoid
Online Access:https://www.mdpi.com/2079-7737/11/3/427

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https://www.mdpi.com/2079-7737/11/3/427

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