Circulating neutrophil extracellular trap (NET)-forming ‘rogue’ neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19—an observational study

Circulating neutrophil extracellular trap (NET)-forming ‘rogue’ neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19—an observational study

Abstract Background Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutrophil/NETs-mediated progression of multi-organ dysfunction. Because of eme...

Full description

Bibliographic Details
Main Authors: Victoria L. M. Herrera, Nicholas A. Bosch, Judith J. Lok, Mai Q. Nguyen, Kaitriona A. Lenae, Joanne T. deKay, Sergey V. Ryzhov, David B. Seder, Nelson Ruiz-Opazo, Allan J. Walkey
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Translational Medicine Communications
Subjects:
COVID-19
Multi-organ failure
NETs
Neutrophil-subsets
DEspR
Mediation analysis
Online Access:https://doi.org/10.1186/s41231-023-00143-x

Internet

https://doi.org/10.1186/s41231-023-00143-x

Similar Items