Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy

Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy

We have shown in vivo and in vitro previously that psychosine causes dysfunction of autophagy and the ubiquitin-proteasome system underlying the pathogenesis of globoid cell leukodystrophy (GLD), a devastating lysosomal storage disease complicated by global demyelination. Here, we investigated the t...

Full description

Bibliographic Details
Main Authors: Dar-Shong Lin, Yu-Wen Huang, Tsung-Han Lee, Lung Chang, Zon-Darr Huang, Tsu-Yen Wu, Tuan-Jen Wang, Che-Sheng Ho
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
psychosine
globoid cell leukodystrophy
Krabbe disease
demyelination
autophagy
ubiquitin-proteasome system
Online Access:https://www.mdpi.com/2073-4409/12/7/993

Internet

https://www.mdpi.com/2073-4409/12/7/993

Similar Items