Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level

Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level

Following interaction with cognate antigens, B cells undergo cell activation, proliferation and differentiation. Ligation of the B cell receptor (BCR) leads to the phosphorylation of BCR-associated signaling proteins within minutes of antigen binding, a process with profound consequences for the fat...

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Bibliographic Details
Main Authors: Franklin R Toapanta, Paula J Bernal, Marcelo B. Sztein
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Salmonella typhi
Streptococcus pneumoniae
Vaccines
Cell signaling
Naïve B cells
IgM memory B cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00128/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00128/full

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