Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits

Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits

Buprenorphine is a mixed opioid receptor agonist-antagonist used in acute and chronic pain management. Although this agent's analgesic effect increases in a dose-dependent manner, buprenorphine-induced respiratory depression shows a marked ceiling effect at higher doses, which is considered to...

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Bibliographic Details
Main Authors: SHIGEKI SAKURABA, MIKI TSUJITA, HIROFUMI ARISAKA, JUNZO TAKEDA, KAZUICHI YOSHIDA, SHUN-ICHI KUWANA
Format: Article
Language:English
Published: BMC 2009-01-01
Series:Biological Research
Subjects:
buprenorphine
donepezil
rabbit
respiratory depression
cholinesterase inhibitor
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000400008

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000400008

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