UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

Abstract KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiquitin-like containing PHD and RING finger domains...

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Bibliographic Details
Main Authors: Kaja Kostyrko, Marta Román, Alex G. Lee, David R. Simpson, Phuong T. Dinh, Stanley G. Leung, Kieren D. Marini, Marcus R. Kelly, Joshua Broyde, Andrea Califano, Peter K. Jackson, E. Alejandro Sweet-Cordero
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39591-2

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https://doi.org/10.1038/s41467-023-39591-2

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