Synthesis, Structural Characterization, and In Vitro and In Silico Antifungal Evaluation of Azo-Azomethine Pyrazoles (PhN<sub>2</sub>(PhOH)CHN(C<sub>3</sub>N<sub>2</sub>(CH<sub>3</sub>)<sub>3</sub>)PhR, R = H or NO<sub>2</sub>)

Synthesis, Structural Characterization, and In Vitro and In Silico Antifungal Evaluation of Azo-Azomethine Pyrazoles (PhN<sub>2</sub>(PhOH)CHN(C<sub>3</sub>N<sub>2</sub>(CH<sub>3</sub>)<sub>3</sub>)PhR, R = H or NO<sub>2</sub>)

The azo-azomethine imines, R<sup>1</sup>-N=N-R<sup>2</sup>-CH=N-R<sup>3</sup>, are a class of active pharmacological ligands that have been prominent antifungal, antibacterial, and antitumor agents. In this study, four new azo-azomethines, R<sup>1</sup>...

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Bibliographic Details
Main Authors: Dorancelly Fernandez, Andrés Restrepo-Acevedo, Cristian Rocha-Roa, Ronan Le Lagadec, Rodrigo Abonia, Susana A. Zacchino, Jovanny A. Gómez Castaño, Fernando Cuenú-Cabezas
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
Schiff bases
azomethine compounds
<i>Candida albicans</i>
<i>Cryptococcus neoformans</i>
in silico studies
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/24/7435

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https://www.mdpi.com/1420-3049/26/24/7435

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