Discovery of a novel dual-targeting D-peptide to block CD24/Siglec-10 and PD-1/PD-L1 interaction and synergize with radiotherapy for cancer immunotherapy

Discovery of a novel dual-targeting D-peptide to block CD24/Siglec-10 and PD-1/PD-L1 interaction and synergize with radiotherapy for cancer immunotherapy

Background Aside from immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1), intervention of CD47/Sirpα mediated ‘don’t eat me’ signal between macrophage and tumor cell is considered as a promising therapeutic approach for cancer immunoth...

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Bibliographic Details
Main Authors: Xiuman Zhou, Chunxia Chen, Guanyu Chen, Wenjie Zhai, Yahong Wu, Yanfeng Gao, Xinghua Sui, Wenhui Shen, Peishang Shi, Qingyu Dong, Wentong Tian, Xueqin Zhu, Xiaoxi Wang, Shengzhe Jin, Lu Qiu
Format: Article
Language:English
Published: BMJ Publishing Group 2023-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/6/e007068.full

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https://jitc.bmj.com/content/11/6/e007068.full

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