Colchicine Depolymerizes Microtubules, Increases Junctophilin‐2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension

Colchicine Depolymerizes Microtubules, Increases Junctophilin‐2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension

BackgroundPulmonary arterial hypertension (PAH) is a lethal disease characterized by obstructive pulmonary vascular remodeling and right ventricular (RV) dysfunction. Although RV function predicts outcomes in PAH, mechanisms of RV dysfunction are poorly understood, and RV‐targeted therapies are lack...

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Bibliographic Details
Main Authors: Kurt W. Prins, Lian Tian, Danchen Wu, Thenappan Thenappan, Joseph M. Metzger, Stephen L. Archer
Format: Article
Language:English
Published: Wiley 2017-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
pulmonary hypertension
right ventricular failure
right ventricular pressure overload
T‐tubules
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006195

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https://www.ahajournals.org/doi/10.1161/JAHA.117.006195

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