Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 Proteins

Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 Proteins

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3) proteins (APOBEC3s) are deaminases that convert cytosines to uracils predominantly on a single-stranded DNA, and function as intrinsic restriction factors in the innate immune system to suppress replication of viruses (incl...

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Bibliographic Details
Main Authors: Yoshiyuki Hakata, Masaaki Miyazawa
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Microorganisms
Subjects:
APOBEC3
deaminase-independent antiretroviral function
innate immunity
Online Access:https://www.mdpi.com/2076-2607/8/12/1976

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