PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells

PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells

Introduction: Human papillomavirus (HPV) integration can induce gene expression dysregulation by destroying higher-order chromatin structure in cervical cancer. Objectives: We established a 13q22 site-specific HPV16 gene knock-in cell model to interrogate the changes in chromatin structure at the in...

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Bibliographic Details
Main Authors: Xiaomin Li, Ci Ren, Anni Huang, Yue Zhao, Liming Wang, Hui Shen, Chun Gao, Bingxin Chen, Tong Zhu, Jinfeng Xiong, Da Zhu, Yafei Huang, Jianlin Ding, Zan Yuan, Wencheng Ding, Hui Wang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Advanced Research
Subjects:
HPV16 integration
Malignant transformation
PIBF1
Chromatin structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223001212

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http://www.sciencedirect.com/science/article/pii/S2090123223001212

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