Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia

Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia

Importance: Statins have been linked to an increased risk for insomnia, but the literature is controversial. Moreover, it is unknown, if the potential effects are directly related to the inhibition of the statin target HMGCR, the subsequently lowered cholesterol levels, or other off-target effects o...

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Bibliographic Details
Main Authors: Ahmed M. Alsehli, Gull Rukh, Laura E. Clemensson, Diana-Maria Ciuculete, Xiao Tan, Mohamed H. Al-Sabri, Michael J. Williams, Christian Benedict, Helgi B. Schiöth
Format: Article
Language:English
Published: IMR Press 2021-12-01
Series:Frontiers in Bioscience-Landmark
Subjects:
statin treatment
genetic variants
insomnia
chronotype
cholesterol-lowering drugs
Online Access:https://www.imrpress.com/journal/FBL/26/12/10.52586/5039

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https://www.imrpress.com/journal/FBL/26/12/10.52586/5039

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