Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling

Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling

Introduction: For the implementation of robust bioprocesses, understanding of temporal cell behavior with respect to relevant inputs is crucial. Intensified Design of Experiments (iDoE) is an efficient tool to assess the joint influence of input parameters by including intra-experimental changes.Met...

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Bibliographic Details
Main Authors: V. Nold, L. Junghans, B. Bayer, L. Bisgen, M. Duerkop, R. Drerup, B. Presser, T. Schwab, E. Bluhmki, S. Wieschalka, B. Knapp
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Chemical Engineering
Subjects:
intensified design of experiments
mammalian biopharmaceutical production
upstream process modeling
multivariate optimization
bioprocess phases
Online Access:https://www.frontiersin.org/articles/10.3389/fceng.2022.1044245/full

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https://www.frontiersin.org/articles/10.3389/fceng.2022.1044245/full

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