Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions

Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions

Reusswig et al. use engineered systems to force DNA replication in the G1 phase of the cell cycle. This unscheduled G1 replication shows hallmarks of S phase replication, but leads to over-replication and DNA breaks from replication collisions.

Bibliographic Details
Main Authors: Karl-Uwe Reusswig, Julia Bittmann, Martina Peritore, Mathilde Courtes, Benjamin Pardo, Michael Wierer, Matthias Mann, Boris Pfander
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34379-2

Internet

https://doi.org/10.1038/s41467-022-34379-2

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