Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

<p>Abstract</p> <p>Background</p> <p>Nucleolin expressed at the cell surface is a binding protein for a variety of ligands implicated in tumorigenesis and angiogenesis. By using a specific antagonist that binds the C-terminal RGG domain of nucleolin, the HB-19 pseudopep...

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Bibliographic Details
Main Authors: Hovanessian Ara G, Soundaramourty Calaiselvy, Nondier Isabelle, El Khoury Diala, Krust Bernard
Format: Article
Language:English
Published: BMC 2011-08-01
Series:BMC Cancer
Subjects:
antitumoral action
surface nucleolin
multivalent pseudopeptides
nucleolin antagonist peptide
anti-inflammatory action
nucleophosmin
Online Access:http://www.biomedcentral.com/1471-2407/11/333

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http://www.biomedcentral.com/1471-2407/11/333

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