Sphingosine-1-phosphate receptor-independent lung endothelial cell barrier disruption induced by FTY720 regioisomers

Rationale Vascular permeability is a hallmark of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury pathobiology; however, the mechanisms underlying this vascular dysregulation remain unclear, thereby impairing the development of desperately needed effective therapeutics....

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Bibliographic Details
Main Authors: Sara M. Camp, Alexander Marciniak, Eddie T. Chiang, Alexander N. Garcia, Robert Bittman, Robin Polt, Ruth G. Perez, Steven M. Dudek, Joe G. N. Garcia
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894020905521