Sex Differences in Mesenchymal Stem Cell Therapy With Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model

Sex Differences in Mesenchymal Stem Cell Therapy With Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model

Mesenchymal stem cell (MSC)-based therapy and novel biomaterials are promising strategies for healing of long bone critical size defects. Interleukin-4 (IL-4) over-expressing MSCs within a gelatin microribbon (µRB) scaffold was previously shown to enhance the bridging of bone within a critical size...

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Bibliographic Details
Main Authors: Masaya Ueno, Ning Zhang, Hirohito Hirata, Danial Barati, Takeshi Utsunomiya, Huaishuang Shen, Tzuhua Lin, Masahiro Maruyama, Ejun Huang, Zhenyu Yao, Joy Y. Wu, Stefan Zwingenberger, Fan Yang, Stuart B. Goodman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
sex differences
bone healing
mesenchymal stem cell
microribbon hydrogel
interleukin-4
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.755964/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.755964/full

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