pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsions
The design of biocompatible multiple emulsions is an important challenge in the field of controlled delivery systems for protecting and delivering compounds encapsulated and protected in the innermost phase. In this paper, we use biocompatible water – Miglyol®812 water-in-oil-in-water (W/O/W) emulsi...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | JCIS Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666934X21000386 |
| _version_ | 1818338204373221376 |
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| author | Marine Protat Noémie Bodin-Thomazo Frédéric Gobeaux Florent Malloggi Jean Daillant Nadège Pantoustier Patrick Perrin Patrick Guenoun |
| author_facet | Marine Protat Noémie Bodin-Thomazo Frédéric Gobeaux Florent Malloggi Jean Daillant Nadège Pantoustier Patrick Perrin Patrick Guenoun |
| author_sort | Marine Protat |
| collection | DOAJ |
| description | The design of biocompatible multiple emulsions is an important challenge in the field of controlled delivery systems for protecting and delivering compounds encapsulated and protected in the innermost phase. In this paper, we use biocompatible water – Miglyol®812 water-in-oil-in-water (W/O/W) emulsions stabilized by a stimuli-responsive diblock copolymer consisting of poly(dimethylsiloxane) (PDMS) and poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) to design an easy-to-process new delivery W/O/W system. Such emulsions are formed in a single emulsification step. They present a high encapsulation yield and are shown to be stable over months. As such, the encapsulation of a hydrophilic dye (Alexa fluor) in the innermost water phase is successfully demonstrated over months. These emulsions are stimulable either by a shift in pH level or in ionic strength. The former destabilizes the multiple emulsion and leads to a simple one while the latter partly maintains the multiple character. Eventually both stimulations are effective in the dye release and molecular mechanisms are proposed for explaining the observed two-stage kinetics of release. |
| first_indexed | 2024-12-13T15:07:24Z |
| format | Article |
| id | doaj.art-bff940b3087c44b48a9994b94746774d |
| institution | Directory Open Access Journal |
| issn | 2666-934X |
| language | English |
| last_indexed | 2024-12-13T15:07:24Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JCIS Open |
| spelling | doaj.art-bff940b3087c44b48a9994b94746774d2022-12-21T23:40:58ZengElsevierJCIS Open2666-934X2022-04-015100039pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsionsMarine Protat0Noémie Bodin-Thomazo1Frédéric Gobeaux2Florent Malloggi3Jean Daillant4Nadège Pantoustier5Patrick Perrin6Patrick Guenoun7Sciences et Ingénierie de la Matière Molle, PSL Research University, ESPCI Paris, CNRS, 10 rue Vauquelin, 75231, Paris cedex 05, France; Université Paris-Saclay, CEA, CNRS, NIMBE, LIONS, 91191, Gif-sur-Yvette, FranceSciences et Ingénierie de la Matière Molle, PSL Research University, ESPCI Paris, CNRS, 10 rue Vauquelin, 75231, Paris cedex 05, France; Université Paris-Saclay, CEA, CNRS, NIMBE, LIONS, 91191, Gif-sur-Yvette, FranceUniversité Paris-Saclay, CEA, CNRS, NIMBE, LIONS, 91191, Gif-sur-Yvette, FranceUniversité Paris-Saclay, CEA, CNRS, NIMBE, LIONS, 91191, Gif-sur-Yvette, FranceSynchrotron Soleil, L'Orme des Merisiers, Saint-Aubin – BP 48, 91192, Gif-sur-Yvette Cedex, FranceSciences et Ingénierie de la Matière Molle, PSL Research University, ESPCI Paris, CNRS, 10 rue Vauquelin, 75231, Paris cedex 05, France; Sciences et Ingénierie de la Matière Molle, Sorbonne Universités, Université Pierre et Marie Curie, Paris, 06, 10 rue Vauquelin, FranceSciences et Ingénierie de la Matière Molle, PSL Research University, ESPCI Paris, CNRS, 10 rue Vauquelin, 75231, Paris cedex 05, France; Sciences et Ingénierie de la Matière Molle, Sorbonne Universités, Université Pierre et Marie Curie, Paris, 06, 10 rue Vauquelin, France; Corresponding author. Sciences et Ingénierie de la Matière Molle, PSL Research University, ESPCI Paris, CNRS, 10 rue Vauquelin, 75231, Paris cedex 05, France.Université Paris-Saclay, CEA, CNRS, NIMBE, LIONS, 91191, Gif-sur-Yvette, France; Corresponding author.The design of biocompatible multiple emulsions is an important challenge in the field of controlled delivery systems for protecting and delivering compounds encapsulated and protected in the innermost phase. In this paper, we use biocompatible water – Miglyol®812 water-in-oil-in-water (W/O/W) emulsions stabilized by a stimuli-responsive diblock copolymer consisting of poly(dimethylsiloxane) (PDMS) and poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) to design an easy-to-process new delivery W/O/W system. Such emulsions are formed in a single emulsification step. They present a high encapsulation yield and are shown to be stable over months. As such, the encapsulation of a hydrophilic dye (Alexa fluor) in the innermost water phase is successfully demonstrated over months. These emulsions are stimulable either by a shift in pH level or in ionic strength. The former destabilizes the multiple emulsion and leads to a simple one while the latter partly maintains the multiple character. Eventually both stimulations are effective in the dye release and molecular mechanisms are proposed for explaining the observed two-stage kinetics of release.http://www.sciencedirect.com/science/article/pii/S2666934X21000386Multiple emulsionW/O/WStimuli-responsive interfaceBlock copolymerEncapsulationTriggered release |
| spellingShingle | Marine Protat Noémie Bodin-Thomazo Frédéric Gobeaux Florent Malloggi Jean Daillant Nadège Pantoustier Patrick Perrin Patrick Guenoun pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsions JCIS Open Multiple emulsion W/O/W Stimuli-responsive interface Block copolymer Encapsulation Triggered release |
| title | pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsions |
| title_full | pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsions |
| title_fullStr | pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsions |
| title_full_unstemmed | pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsions |
| title_short | pH and ionic strength triggered destabilization of biocompatible stable water-in-oil-in-water (W/O/W) emulsions |
| title_sort | ph and ionic strength triggered destabilization of biocompatible stable water in oil in water w o w emulsions |
| topic | Multiple emulsion W/O/W Stimuli-responsive interface Block copolymer Encapsulation Triggered release |
| url | http://www.sciencedirect.com/science/article/pii/S2666934X21000386 |
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