Boost immunizations with NA-derived peptide conjugates achieve induction of NA inhibition antibodies and heterologous influenza protections

Summary: Neuraminidase is suggested as an important component for developing a universal influenza vaccine. Targeted induction of neuraminidase-specific broadly protective antibodies by vaccinations is challenging. To overcome this, we rationally select the highly conserved peptides from the consens...

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Main Authors: De-Jian Liu, Cui-Cui Liu, Xiu-Qin Zhong, Xuan Wu, Hui-Hui Zhang, Shang-Wen Lu, Zhuo-Ling Shen, Wen-Wen Song, Shi-Long Zhao, You-Song Peng, He-Ping Zheng, Mu-Yang Wan, Yao-Qing Chen, Lei Deng
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007775