L2Δ13, a splicing isoform of lysyl oxidase-like 2, causes adipose tissue loss via the gut microbiota and lipid metabolism

L2Δ13, a splicing isoform of lysyl oxidase-like 2, causes adipose tissue loss via the gut microbiota and lipid metabolism

Summary: Obesity is primarily characterized by the dysregulation of lipid metabolism and gut microbiota. Here, we found that the body weight of transgenic mice overexpressing L2Δ13, a selectively spliced isoform of lysyl oxidase-like 2 (LOXL2), was lower than that of wild-type (WT) mice. Numerous mi...

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Bibliographic Details
Main Authors: Yang Chen, Li-Xia He, Jin-Ling Chen, Xin Xu, Juan-Juan Wang, Xiu-Hui Zhan, Ji-Wei Jiao, Geng Dong, En-Min Li, Li-Yan Xu
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Lipid
Microbiome
Microbial metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422201166X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422201166X

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