The Aryl Hydrocarbon Receptor Ligand FICZ Improves Left Ventricular Remodeling and Cardiac Function at the Onset of Pressure Overload-Induced Heart Failure in Mice

The Aryl Hydrocarbon Receptor Ligand FICZ Improves Left Ventricular Remodeling and Cardiac Function at the Onset of Pressure Overload-Induced Heart Failure in Mice

Adverse ventricular remodeling is the heart’s response to damaging stimuli and is linked to heart failure and poor prognosis. Formyl-indolo [3,2-b] carbazole (FICZ) is an endogenous ligand for the aryl hydrocarbon receptor (AhR), through which it exerts pleiotropic effects including protection again...

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Bibliographic Details
Main Authors: María Tamayo, Laura Martín-Nunes, María José Piedras, María Martin-Calvo, Daniel Martí-Morente, Marta Gil-Fernández, Nieves Gómez-Hurtado, María Ángeles Moro, Lisardo Bosca, María Fernández-Velasco, Carmen Delgado
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
aryl hydrocarbon receptor (AhR)
fibrosis
cardiac hypertrophy
oxidative stress
cardiac remodeling
formyl-indolo [3,2-b] carbazole (FICZ)
Online Access:https://www.mdpi.com/1422-0067/23/10/5403

Internet

https://www.mdpi.com/1422-0067/23/10/5403

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