Segmental duplication as potential biomarkers for non-invasive prenatal testing of aneuploidies

Segmental duplication as potential biomarkers for non-invasive prenatal testing of aneuploidies

Background: Segmental duplication (SD) regions are distinct targets for aneuploidy detection owing to the virtual elimination of amplification bias. The difficulty of searching SD sequences for assay design has hampered their applications. Methods: We developed a computational program, ChAPDes, whic...

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Bibliographic Details
Main Authors: Xinwen Chen, Yifan Li, Qiuying Huang, Xingming Lin, Xudong Wang, Yafang Wang, Ying Liu, Qiushun He, Yinghua Liu, Ting Wang, Zhi-Liang Ji, Qingge Li
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EBioMedicine
Subjects:
Segmental duplications
Computational program
Chromosome aneuploidy
Digital PCR
Prenatal diagnosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421003285

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http://www.sciencedirect.com/science/article/pii/S2352396421003285

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