The Combination of an mRNA Immunogen, a TLR7 Agonist and a PD1 Blocking Agent Enhances In-Vitro HIV T-Cell Immune Responses

The Combination of an mRNA Immunogen, a TLR7 Agonist and a PD1 Blocking Agent Enhances In-Vitro HIV T-Cell Immune Responses

The development of new strategies to achieve a functional cure for HIV remains a priority. We tested a novel HIV therapeutic vaccine using unmodified mRNA (TMEP-B) and mRNA modified by 1-methyl-3′-pseudouridylyl (TMEP-Bmod) expressing both a multiepitopic sequences from Gag, Pol, and Nef proteins, i...

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Bibliographic Details
Main Authors: Lorena Usero, Lorna Leal, Carmen Elena Gómez, Laia Miralles, Elena Aurrecoechea, Ignasi Esteban, Berta Torres, Alexy Inciarte, Beatriz Perdiguero, Mariano Esteban, Felipe García, Montserrat Plana
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Vaccines
Subjects:
HIV
mRNA
vaccine
dendritic cells
immunomodulators
functional cure
Online Access:https://www.mdpi.com/2076-393X/11/2/286

Internet

https://www.mdpi.com/2076-393X/11/2/286

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