STORE-OPERATED CA2+ ENTRY (SOCE) AND PURINERGIC RECEPTOR-MEDIATED CA2+ HOMEOSTASIS IN MURINE BV2 MICROGLIA CELLS: EARLY CELLULAR RESPONSES TO ATP-MEDIATED MICROGLIA ACTIVATION

STORE-OPERATED CA2+ ENTRY (SOCE) AND PURINERGIC RECEPTOR-MEDIATED CA2+ HOMEOSTASIS IN MURINE BV2 MICROGLIA CELLS: EARLY CELLULAR RESPONSES TO ATP-MEDIATED MICROGLIA ACTIVATION

Microglia activation is a neuro-inflammatory response to parenchymal damage with release of intracellular metabolites, e.g. purines, and signaling molecules from damaged cells. Extracellular purines can elicit Ca2+-mediated microglia activation involving P2X/P2Y receptors with metabotropic (P2Y) and...

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Bibliographic Details
Main Authors: Daniel F. Gilbert, Martin James Stebbing, Katharina Kuenzel, Robyn Murphy, Evelyn Zacharewicz, Andreas Buttgereit, Leanne Stokes, David J. Adams, Oliver Friedrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Calcium
ATP
Multiphoton imaging
store-operated calcium entry
high-content screening
bv2 microglia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00111/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00111/full

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